Modelling of oligodextran production via an immobilized enzyme membrane reactor: Bioreaction-separation coupling mechanism

• The performance of immobilized EMR for oligodextran production is modeled. efficiency an strongly dependent on the mass-transport limitations. Kinetics enzymatic reaction should match membrane filtration performance. Increasing selectivity and transmission benefits efficiency. Free using higher enzyme concentration could compete with EMR. Use reactors (EMR) effective strategy to enhance Nevertheless, reaction-separation coupling mechanism has not been fully understood. In this study, we developed a model disentangle interaction behind separation phenomena in eventually evaluate process optimal production. simulation results show that applying substrate feeding mode high operating pressure enhances convective diffusive flows through membrane, leading transport rate product. loading amount need permeability order ensure rapid removal target oligodextrans. Therefore, membranes permselectivity are required obtaining desirable product quality. Although at beginning because local zone, free enzymes outperform by due its larger area as continues. Our study provides deep insights into enhancement.